Concerning V:TM the most important difference to other classical RPGs are what's the most valuable thing and the least valuable thing your character has.
In D&D for example your gold or your magic items can be your greatest treasure and your life is maybe not _that_ important because there's always a good cleric which can resurrect you in the next capital city.
In V:TM your resuorces are not that important.
Even time is of no great matter. Hey, you are immortal. Who cares about a few more decades?
Or a few more minions wasted in some fight?
But your (un)life on the other hand is the greatest treasure you have.
You want to protect it as much as you can. At least once you have lived a few ten or hundert years.
Younger vampires are maybe a little more selfdestructive.
So it's the players job to work, plan and plot carefully and without haste.
Who care's about if your oponent dies today or in 50 years?
Or wait... why kill him at all? Why not bloodbind him or her?
Or, or, or...
And then there are those situations where the real actions takes place and things are dangerous and hasty.
This is when you pull al the triggers you prepared and where you bring in your minions (especially during the day). Or - depending on your characters clan and concept - where you embrace the beast and the predator inside of you and gather all the magic and bloodpower you've got to strike your foces damn bad with the unholy and unnatural force you are.
*smile* Remindes me of the good old times when I played my overpowered badass citygangrel. It was a LARP character which had evolved over a few years.
He belonged to covered ops Sabbath pack that infiltrated local Camarilla structures. Until another Sabath pack killed most of his pack. *grins*
You might be able to imagine what happens when an almost almost 100 year old vampire with mid to high ranks of fortitude, potency, promethean, obfuscate and celerity and a little history of diablery (correct in English) goes hunting the murders of his "child" and "family".
I'd like to continue his hunt one day. Maybe more a good idea for a story than a LARP.